Kujambula zithunzi zachipatala nthawi zambiri kumathandiza kuzindikira ndi kuchiza matenda a khansa. Makamaka, kujambula zithunzi zamaginito (MRI) kumagwiritsidwa ntchito kwambiri chifukwa cha kuwala kwake kwakukulu, makamaka pogwiritsa ntchito zinthu zotsutsana.
Kafukufuku watsopano wofalitsidwa mu magazini ya Advanced Science akufotokoza za mankhwala atsopano odzipangira okha omwe angathandize kuwona bwino zotupa kudzera mu MRI.
Kodi kusiyana ndi chiyani?zofalitsa nkhani?
Mankhwala oletsa kusiyanitsa (omwe amadziwikanso kuti mankhwala oletsa kusiyanitsa) ndi mankhwala omwe amalowetsedwa (kapena kutengedwa) m'thupi la munthu kapena ziwalo kuti awonjezere kuwona zithunzi. Mankhwalawa ndi okhuthala kapena otsika kuposa minofu yozungulira, zomwe zimapangitsa kuti mankhwalawa agwiritsidwe ntchito kuwonetsa zithunzi ndi zida zina. Mwachitsanzo, mankhwala okonzekera ayodini, barium sulfate, ndi zina zotero amagwiritsidwa ntchito kwambiri poyang'anira X-ray. Amalowetsedwa m'mitsempha yamagazi ya wodwalayo kudzera mu syringe yolimbana ndi kupanikizika kwambiri.
Pa nanoscale, mamolekyu amakhalabe m'magazi kwa nthawi yayitali ndipo amatha kulowa m'matenda olimba popanda kuyambitsa njira zodzitetezera ku matenda a chotupa. Mamolekyu angapo opangidwa ndi ma nanomolecules aphunziridwa ngati omwe angayambitse CA kukhala zotupa.
Mankhwala osiyanitsa a nanoscale (NCAs) amenewa ayenera kugawidwa bwino pakati pa magazi ndi minofu yofunikira kuti achepetse phokoso lakumbuyo ndikupeza chiŵerengero chachikulu cha chizindikiro-ku-phokoso (S/N). Pa kuchuluka kwakukulu, NCA imakhalabe m'magazi kwa nthawi yayitali, motero imawonjezera chiopsezo cha fibrosis yayikulu chifukwa cha kutulutsidwa kwa ma ayoni a gadolinium kuchokera ku complex.
Mwatsoka, ma NCA ambiri omwe amagwiritsidwa ntchito pano ali ndi magulu a mitundu yosiyanasiyana ya mamolekyu. Pansi pa malire enaake, ma micelles kapena ma aggregates awa nthawi zambiri amalekanitsidwa, ndipo zotsatira za chochitikachi sizikudziwika bwino.
Izi zinalimbikitsa kafukufuku wokhudza ma macromolecule a nanoscale omwe amapinda okha omwe alibe malire ofunikira. Izi zimakhala ndi mafuta amkati ndi gawo lakunja losungunuka lomwe limalepheretsanso kuyenda kwa mayunitsi osungunuka pamwamba pa malo olumikizirana. Izi zitha kukhudza magawo opumula a mamolekyulu ndi ntchito zina zomwe zitha kusinthidwa kuti ziwonjezere kuperekedwa kwa mankhwala ndi mawonekedwe apadera mu thupi.
Chojambulira chosiyanitsa nthawi zambiri chimalowetsedwa m'thupi la wodwalayo kudzera mu injector yosiyanitsa yothamanga kwambiri.LnkMed, wopanga akatswiri omwe amayang'ana kwambiri kafukufuku ndi chitukuko cha majekiseni osiyanitsa mitundu ndi zinthu zina zothandizira, wagulitsa zakeCT, MRIndiDSAma injectors kunyumba ndi kunja ndipo adziwika ndi msika m'maiko ambiri. Fakitale yathu imatha kupereka chithandizo chonsezogwiritsidwa ntchitoyomwe ndi yotchuka kwambiri m'zipatala. Fakitale yathu ili ndi njira zowunikira bwino kwambiri zopangira katundu, kutumiza mwachangu, komanso ntchito yokwanira komanso yothandiza pambuyo pogulitsa. Ogwira ntchito onse aLnkMedtikuyembekeza kutenga nawo mbali kwambiri mumakampani opanga angiography mtsogolo, kupitiriza kupanga zinthu zapamwamba kwambiri kwa makasitomala, ndikupereka chisamaliro kwa odwala.
Kodi kafukufukuyu akusonyeza chiyani?
Njira yatsopano yayambitsidwa mu NCA yomwe imawonjezera kupumula kwa ma proton kwa nthawi yayitali, zomwe zimapangitsa kuti ipange zithunzi zakuthwa kwambiri pa gadolinium complexes yotsika kwambiri. Kutsitsa pang'ono kumachepetsa chiopsezo cha zotsatirapo zoyipa chifukwa mlingo wa CA ndi wochepa.
Chifukwa cha mphamvu yodzipinda yokha, SMDC yomwe imachokera imakhala ndi pakati pothina komanso malo odzaza anthu ambiri. Izi zimawonjezera kumasuka pamene kuyenda kwamkati ndi kwagawo kuzungulira mawonekedwe a SMDC-Gd kungakhale koletsedwa.
NCA iyi imatha kudziunjikira mkati mwa zotupa, zomwe zimapangitsa kuti zikhale zotheka kugwiritsa ntchito chithandizo cha Gd neutron capture pochiza zotupa mwapadera komanso moyenera. Mpaka pano, izi sizinachitike mwachipatala chifukwa chosowa kusankha kupereka 157Gd ku zotupa ndikuzisunga pamlingo woyenera. Kufunika kopereka mlingo waukulu kumakhudzana ndi zotsatira zoyipa komanso zotsatira zoyipa chifukwa kuchuluka kwa gadolinium kozungulira chotupacho kumachiteteza ku kukhudzana ndi neutron.
Nanoscale imathandizira kusonkhanitsa kwa mankhwala osiyanasiyana komanso kugawa bwino mankhwala mkati mwa zotupa. Mamolekyu ang'onoang'ono amatha kutuluka m'mitsempha yamagazi, zomwe zimapangitsa kuti pakhale mphamvu yayikulu yotsutsana ndi chotupa.
“Popeza kuti kukula kwa SMDC kuli kochepera 10 nm, zomwe tapeza zikuchokera ku kulowa kwakuya kwa SMDC m'matenda, zomwe zimathandiza kuthawa mphamvu yoteteza ma neutron a kutentha ndikuwonetsetsa kuti ma elekitironi ndi ma gamma rays afalikira bwino pambuyo poti neutron ya kutentha yakhudzidwa.“
Kodi zotsatira zake ndi zotani?
"Zingathandize kupanga ma SMDC abwino kwambiri kuti apeze matenda a chotupa, ngakhale pakufunika jakisoni wambiri wa MRI."
"Zomwe tapeza zikuwonetsa kuthekera kokonza NCA kudzera mu kapangidwe ka mamolekyulu odzipinda okha ndikuwonetsa kupita patsogolo kwakukulu pakugwiritsa ntchito NCA pozindikira ndi kuchiza khansa."
Nthawi yotumizira: Dec-08-2023
