Kafukufuku watsopano wotchedwa “Utilizing Pix-2-Pix GAN for Deep Learning-Based Whole-Body PSMA PET/CT Attenuation Correction” wafalitsidwa posachedwapa mu Volume 15 ya Oncotarget pa Meyi 7, 2024.
Kuwonekera kwa kuwala kwa dzuwa kuchokera ku maphunziro otsatizana a PET/CT potsatira odwala a khansa ndi nkhani yodetsa nkhawa. Mu kafukufuku waposachedwapa, gulu la ofufuza kuphatikizapo Kevin C. Ma, Esther Mena, Liza Lindenberg, Nathan S. Lay, Phillip Eclarinal, Deborah E. Citrin, Peter A. Pinto, Bradford J. Wood, William L. Dahut, James L. Gulley, Ravi A. Madan, Peter L. Choyke, Ismail Baris Turkbey, ndi Stephanie A. Harmon ochokera ku National Cancer Institute ku National Institutes of Health adayambitsa chida cha artificial intelligence (AI). Cholinga cha chida ichi ndikupanga zithunzi za attenuation-corrected PET (AC-PET) kuchokera ku zithunzi za non-attenuation-corrected PET (NAC-PET), zomwe zingachepetse kufunikira kwa ma CT scans otsika.
"Zithunzi za PET zopangidwa ndi AI zili ndi kuthekera kwachipatala kochepetsa kufunikira kokonza kuchepetsedwa kwa CT scans pomwe zikusunga zizindikiro zowerengera ndi khalidwe la chithunzi cha odwala khansa ya prostate."
Njira: Njira yophunzirira mozama yochokera pa kapangidwe ka 2D Pix-2-Pix generative adversarial network (GAN) idapangidwa kutengera zithunzi za AC-PET ndi NAC-PET. Kafukufuku wa 18F-DCFPyL PSMA (Prostate-specific membrane antigen) PET-CT wa odwala 302 omwe ali ndi khansa ya prostate adagawidwa m'magulu ophunzitsira, kutsimikizira, ndi kuyesa (n 183, 60, ndi 59, motsatana). Chitsanzocho chinaphunzitsidwa pogwiritsa ntchito njira ziwiri zokhazikika: Standard Uptake Value (SUV) yochokera ku SUV-NYUL yochokera ku SUV. Kusanthula magwiridwe antchito opingasa kunayesedwa pogwiritsa ntchito normalized mean square error (NMSE), mean absolute error (MAE), structural similarity index (SSIM) ndi peak signal-to-noise ratio (PSNR). Dokotala wa nuclear medicine adachita kafukufuku wa lesion level of the area of interest. Zizindikiro za SUV zinayesedwa pogwiritsa ntchito intra-group correlation coefficient (ICC), repeatability coefficient (RC), ndi linear mixed effects models.
Zotsatira：Mu gulu loyesera lodziyimira pawokha, apakati a NMSE, MAE, SSIM, ndi PSNR anali 13.26%, 3.59%, 0.891, ndi 26.82, motsatana. ICC ya SUVmax ndi SUV mean inali 0.88 ndi 0.89, zomwe zikusonyeza mgwirizano wamphamvu pakati pa zizindikiro zoyambirira ndi zowunikira zomwe zinapangidwa ndi AI. Zinthu monga malo a zilonda, kuchulukana (mayunitsi a Hounsfield), ndi kutengedwa kwa zilonda zinapezeka kuti zimakhudza cholakwika cha relative mu SUV metrics zopangidwa (zonse p < 0.05).
"AC-PET yopangidwa ndi Pix-2-Pix GAN model ikuwonetsa ziwerengero za SUV zomwe zimagwirizana bwino ndi zithunzi zoyambirira. Zithunzi za PET zopangidwa ndi AI zikuwonetsa kuthekera kwachipatala kothandiza kuchepetsa kufunikira kwa CT scans kuti zichepetse kufooka kwa thupi komanso kusunga zizindikiro zowerengera ndi khalidwe la chithunzi."
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Monga tonse tikudziwira, chitukuko cha makampani opanga zithunzi zachipatala sichingasiyanitsidwe ndi chitukuko cha zida zamankhwala zingapo - majekeseni osiyanitsa ndi zinthu zina zothandizira - zomwe zimagwiritsidwa ntchito kwambiri m'munda uno. Ku China, komwe kumadziwika ndi makampani opanga zinthu, kuli opanga ambiri otchuka kunyumba ndi kunja chifukwa chopanga zida zojambula zithunzi zachipatala, kuphatikizapoLnkMedKuyambira pomwe idakhazikitsidwa, LnkMed yakhala ikuyang'ana kwambiri pa ntchito yopangira majekeseni otsutsana ndi mpweya woipa kwambiri. Gulu la mainjiniya la LnkMed limatsogozedwa ndi PhD yokhala ndi zaka zoposa khumi zokumana nazo ndipo ikuchita kafukufuku ndi chitukuko mozama. Motsogozedwa ndi iye,Injector ya mutu umodzi ya CT,Injector ya mutu wa CT iwiri,Injector ya MRI contrastndiInjector yotsutsana ndi kuthamanga kwa magazi (Angiography)Zapangidwa ndi zinthu izi: thupi lolimba komanso laling'ono, mawonekedwe osavuta komanso anzeru ogwirira ntchito, ntchito zake zonse, chitetezo champhamvu, komanso kapangidwe kolimba. Tikhozanso kupereka ma syringe ndi ma chubu omwe amagwirizana ndi mitundu yotchuka ya ma injector a CT, MRI, DSA Ndi malingaliro awo oona mtima komanso mphamvu zawo zaukadaulo, antchito onse a LnkMed akukupemphani kuti mubwere kudzafufuza misika yambiri pamodzi.
Nthawi yotumizira: Meyi-14-2024
