Kupititsa patsogolo chisamaliro cha odwala ndi AI-Based Attenuation Correction mu PET Imaging

Kafukufuku watsopano wotchedwa "Kugwiritsa Pix-2-Pix GAN for Deep Learning-Based Whole-Body PSMA PET/CT Attenuation Correction" lasindikizidwa posachedwa mu Voliyumu 15 ya Oncotarget pa Meyi 7, 2024.

Kuwonekera kwa ma radiation kuchokera ku kafukufuku wotsatizana wa PET/CT pakutsata kwa odwala oncology ndikodetsa nkhawa. Pakafukufuku waposachedwapa, gulu la ochita kafukufuku kuphatikizapo Kevin C. Ma, Esther Mena, Liza Lindenberg, Nathan S. Lay, Phillip Eclarinal, Deborah E. Citrin, Peter A. Pinto, Bradford J. Wood, William L. Dahut, James L. Gulley, Ravi A. Madan, Peter L. Choyke, Ismail Baris Turkbey, ndi Stephanie A. Harmon ochokera ku National Cancer Institute ku National Institutes of Health adayambitsa chida cha intelligence (AI). Chida ichi cholinga chake ndi kupanga zithunzi za PET (AC-PET) zokonzedwa bwino kuchokera ku zithunzi za PET (NAC-PET) zomwe sizingachepetse, zomwe zingathe kuchepetsa kufunikira kwa CT scans ya mlingo wochepa.

"Zithunzi za PET zopangidwa ndi Ai zili ndi kuthekera kwachipatala kuti zichepetse kufunika kowongolera pa CT scans ndikusunga zolembera komanso mawonekedwe azithunzi za odwala khansa ya prostate."

Njira: Njira yophunzirira mwakuya yozikidwa pa kamangidwe ka 2D Pix-2-Pix generative adversarial network (GAN) idapangidwa kutengera zithunzi za AC-PET ndi NAC-PET. The 18F-DCFPyL PSMA (Prostate-specific membrane antigen) PET-CT kuphunzira kwa odwala 302 omwe ali ndi khansa ya prostate adagawidwa kukhala magulu ophunzitsira, ovomerezeka, ndi oyesa (n 183, 60, ndi 59, motsatira). Chitsanzocho chinaphunzitsidwa pogwiritsa ntchito njira ziwiri zokhazikika: Standard Uptake Value (SUV) yochokera ku SUV-NYUL. Kusanthula koyang'ana kopingasa kunayesedwa pogwiritsa ntchito cholakwika chokhazikika chapakati (NMSE), cholakwika chamtheradi (MAE), index of structural similarity index (SSIM) ndi peak sign-to-noise ratio (PSNR). Dokotala wamankhwala a nyukiliya mwachiyembekezo adapanga kuwunika kwapang'onopang'ono kwa malo omwe akufuna. Zizindikiro za SUV zidawunikidwa pogwiritsa ntchito intra-group coefficient (ICC), repeatability coefficient (RC), ndi zitsanzo zosakanikirana zosakanikirana.

Zotsatira:Mu gulu lodziyimira lodziyimira pawokha, apakati a NMSE, MAE, SSIM, ndi PSNR anali 13.26%, 3.59%, 0.891, ndi 26.82, motsatana. ICC ya SUVmax ndi SUVmean inali 0.88 ndi 0.89, kusonyeza kugwirizana kwakukulu pakati pa zolembera zoyamba ndi za AI zopangidwa ndi kuchuluka kwa zithunzi. Zinthu monga malo otupa, kachulukidwe (mayunitsi a Hounsfield), ndi kutengeka kwa zilonda zinapezeka kuti zimakhudza cholakwika chamtundu wa SUV metrics (yonse p <0.05).

"AC-PET yopangidwa ndi mtundu wa Pix-2-Pix GAN imawonetsa ma metric a SUV omwe amagwirizana kwambiri ndi zithunzi zoyambirira. Zithunzi za PET zopangidwa ndi AI zikuwonetsa kuthekera kwachipatala komwe kungachepetse kufunikira kwa ma scan a CT kuti awongoleredwe ndikusunga zolembera komanso mawonekedwe azithunzi. ”

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Monga tonse tikudziwira, chitukuko cha makampani opanga zithunzi zachipatala sichingasiyanitsidwe ndi chitukuko cha zida zachipatala - majekeseni osiyanitsa ndi mankhwala omwe amawathandiza - omwe amagwiritsidwa ntchito kwambiri pa ntchitoyi. Ku China, komwe kumadziwika chifukwa chamakampani opanga zinthu, pali opanga ambiri otchuka kunyumba ndi kunja chifukwa chopanga zida zofananira zamankhwala, kuphatikizaLnkMed. Chiyambireni kukhazikitsidwa kwake, LnkMed yakhala ikuyang'ana kwambiri pa majekeseni ophatikizika kwambiri. Gulu la engineering la LnkMed limatsogozedwa ndi Ph.D. ali ndi zaka zopitilira khumi ndipo ali wotanganidwa kwambiri ndi kafukufuku ndi chitukuko. Motsogozedwa ndi iye, aCT single head injector,CT double mutu jekeseni,Injector yofananira ya MRI,ndiAngiography high-pressure jekeseni wothandizirazidapangidwa ndi izi: thupi lolimba komanso lolumikizana, mawonekedwe osavuta komanso anzeru ogwirira ntchito, ntchito zonse, chitetezo chokwanira, komanso kapangidwe kolimba. Tithanso kupereka majakisoni ndi machubu omwe amagwirizana ndi ma jakisoni otchuka a CT,MRI,DSA Ndi malingaliro awo owona komanso mphamvu zamaluso, onse ogwira ntchito ku LnkMed akukuitanani mowona mtima kuti mubwere kudzayendera limodzi misika yambiri.